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to answer your question: YES, it is possible to still have problems when taking prilosec, zegerid, nexium, protonix, etc. etc. YOU STILL HAVE TO WATCH WHAT YOU EAT! For this reason I avoid ALL foods w/tomato base. I LOVE sloppy joes and pizza and still eat them occasionally but every time I do I pay for it big time...also regular OJ, anything greasy or spicy...I eat a VERY bland diet! I LOVE salsa...mild that is, but can't eat it. There are so many things I can't eat that people in my family all make fun of me. Plus I have to eat dinner by 6 p.m. or I am bound to have gerd anyway. It is depressing! But I have learned to live w/it or else suffer every day!